Effect on the wound ● Reduction of the wound area due to negative pressure acting on the foam, pulls together the edges of the wound (wound retraction)
● Stimulation of granulation tissue formation in an optimally moist wound environment; in several situations even over bradytrophic tissue such as tendons and bone NPWT was able to stimulate granulation tissue formation ● Continuation of effective mechanical wound cleansing (removal of small tissue debris by suction)
● Effective biochemical reduction of the fluid concentration of wound healing-impairing proteases (such as elastase)—in the first days
● Reliable, continuous removal of wound exudate (and, consequently, fewer dressing changes) within a closed system
● Pressure-related reduction of interstitial oedema with consecutive improvement of microcirculation, stimulation of blood flow and oxygenation.